3EW3

the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor

Summary for 3EW3

Entry DOI	10.2210/pdb3ew3/pdb
Descriptor	Prolactin, Prolactin receptor (2 entities in total)
Functional Keywords	complex, glycoprotein, hormone, lactation, secreted, alternative splicing, membrane, receptor, transmembrane, hormone-hormone receptor complex, hormone/hormone receptor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01236 Membrane; Single-pass type I membrane protein: P05710
Total number of polymer chains	3
Total formula weight	75680.19
Authors	Broutin, I.,Jomain, J.B.,England, P.,Goffin, V. (deposition date: 2008-10-14, release date: 2009-11-03, Last modification date: 2023-11-01)
Primary citation	Broutin, I.,Jomain, J.B.,Tallet, E.,van Agthoven, J.,Raynal, B.,Hoos, S.,Kragelund, B.B.,Kelly, P.A.,Ducruix, A.,England, P.,Goffin, V. Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2. J.Biol.Chem., 285:8422-8433, 2010 Cited by PubMed: 20053995 DOI: 10.1074/jbc.M109.089128 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.8 Å)

Structure validation