3EQY

Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor

Summary for 3EQY

• Entry DOI: 10.2210/pdb3eqy/pdb
• Related: 2Z5S 2Z5T 3DAB 3DAC 3EQS
• Descriptor: Mdm4 protein, 12-mer peptide inhibitor, GUANIDINE, ... (5 entities in total)
• Functional Keywords: mdm4, mdmx, mdmx-peptide inhibitor complex, oncoprotein, metal-binding, nucleus, zinc-finger
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O15151
• Total number of polymer chains: 4
• Total formula weight: 22503.72

Authors

Pazgier, M.,Lu, W. (deposition date: 2008-10-01, release date: 2009-03-17, Last modification date: 2023-09-06)

• Primary citation: Pazgier, M.,Liu, M.,Zou, G.,Yuan, W.,Li, C.,Li, C.,Li, J.,Monbo, J.,Zella, D.,Tarasov, S.G.,Lu, W.; Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.; Proc.Natl.Acad.Sci.USA, 106:4665-4670, 2009; PubMed: 19255450; DOI: 10.1073/pnas.0900947106

Experimental method

X-RAY DIFFRACTION (1.63 Å)