3EPZ

Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1

Summary for 3EPZ

• Entry DOI: 10.2210/pdb3epz/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 1, ZINC ION, beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: winged helix domain, sh3-like barrel, cell cycle, metal binding, dna binding, dna replication, transcriptional silencing, chromatin, phosphorylation, transcription, transcription regulation, transferase, epigenetics zinc, zinc-finger, methyltransferase, nucleus, phosphoprotein, repressor, s-adenosyl-l-methionine, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 61256.43

Authors

Walker, J.R.,Avvakumov, G.V.,Xue, S.,Li, Y.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-09-30, release date: 2008-11-25, Last modification date: 2020-07-29)

• Primary citation: Syeda, F.,Fagan, R.L.,Wean, M.,Avvakumov, G.V.,Walker, J.R.,Xue, S.,Dhe-Paganon, S.,Brenner, C.; The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.; J.Biol.Chem., 286:15344-15351, 2011; PubMed: 21389349; DOI: 10.1074/jbc.M110.209882

Experimental method

X-RAY DIFFRACTION (2.31 Å)