3EOC

Cdk2/CyclinA complexed with a imidazo triazin-2-amine

Summary for 3EOC

Entry DOI	10.2210/pdb3eoc/pdb
Descriptor	Cell division protein kinase 2, Cyclin-A2, 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (3 entities in total)
Functional Keywords	cdk, cyclin, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, nucleus, transferase-cell cycle complex, transferase/cell cycle
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	128470.85
Authors	Cheung, M.,Kuntz, K.,Pobanz, M.,Salovich, J.,Wilson, B.,Andrews, W.,Shewchuk, L.,Epperly, A.,Hassler, D.,Leesnitzer, M.,Smith, J.,Smith, G.,Lansing, T.,Mook, R. (deposition date: 2008-09-26, release date: 2008-11-04, Last modification date: 2023-09-06)
Primary citation	Cheung, M.,Kuntz, K.W.,Pobanz, M.,Salovich, J.M.,Wilson, B.J.,Andrews, C.W.,Shewchuk, L.M.,Epperly, A.H.,Hassler, D.F.,Leesnitzer, M.A.,Smith, J.L.,Smith, G.K.,Lansing, T.J.,Mook, R.A. Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. Bioorg.Med.Chem.Lett., 18:6214-6217, 2008 Cited by PubMed: 18929484 DOI: 10.1016/j.bmcl.2008.09.100 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation