3ELM

Crystal Structure of MMP-13 Complexed with Inhibitor 24f

Summary for 3ELM

Entry DOI	10.2210/pdb3elm/pdb
Descriptor	Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	metallo-enzyme, mmp-13, carboxylate inhibitor, calcium, collagen degradation, disease mutation, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
Biological source	Homo sapiens (Human)
Cellular location	Secreted, extracellular space, extracellular matrix : P45452
Total number of polymer chains	2
Total formula weight	40034.20
Authors	Kulathila, R.,Monovich, L.,Koehn, J. (deposition date: 2008-09-22, release date: 2009-07-21, Last modification date: 2024-02-21)
Primary citation	Monovich, L.G.,Tommasi, R.A.,Fujimoto, R.A.,Blancuzzi, V.,Clark, K.,Cornell, W.D.,Doti, R.,Doughty, J.,Fang, J.,Farley, D.,Fitt, J.,Ganu, V.,Goldberg, R.,Goldstein, R.,Lavoie, S.,Kulathila, R.,Macchia, W.,Parker, D.T.,Melton, R.,O'Byrne, E.,Pastor, G.,Pellas, T.,Quadros, E.,Reel, N.,Roland, D.M.,Sakane, Y.,Singh, H.,Skiles, J.,Somers, J.,Toscano, K.,Wigg, A.,Zhou, S.,Zhu, L.,Shieh, W.C.,Xue, S.,McQuire, L.W. Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13 J.Med.Chem., 52:3523-3538, 2009 Cited by PubMed: 19422229 DOI: 10.1021/jm801394m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation