3EKZ

Structural Characterization of tetrameric Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase - substrate binding and catalysis mechanism of a class IIa bacterial aldolase

Summary for 3EKZ

• Entry DOI: 10.2210/pdb3ekz/pdb
• Related: 3EKL 3ELF
• Descriptor: Fructose-bisphosphate aldolase, 1,3-DIHYDROXYACETONEPHOSPHATE, SN-GLYCEROL-3-PHOSPHATE, ... (6 entities in total)
• Functional Keywords: class ii fructose-1, 6-bisphosphate aldolase, zinc enzyme, mycobacterium tuberculosis, dihydroxyacetone, glyceraldehyde-3-phosphate, aldol condensation, glycolysis, lyase, metal-binding, zinc
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 37942.10

Authors

Pegan, S.,Rukseree, K.,Franzblau, S.G.,Mesecar, A.D. (deposition date: 2008-09-19, release date: 2009-02-10, Last modification date: 2023-08-30)

• Primary citation: Pegan, S.D.,Rukseree, K.,Franzblau, S.G.,Mesecar, A.D.; Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis; J.Mol.Biol., 386:1038-1053, 2009; PubMed: 19167403; DOI: 10.1016/j.jmb.2009.01.003

Experimental method

X-RAY DIFFRACTION (2.07 Å)