3E7O

Crystal Structure of JNK2

Summary for 3E7O

Entry DOI	10.2210/pdb3e7o/pdb
Descriptor	Mitogen-activated protein kinase 9, N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide (3 entities in total)
Functional Keywords	map kinase insert, activation loop, indazole inhibitor, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P45984
Total number of polymer chains	2
Total formula weight	83283.59
Authors	Kuglstatter, A.,Villasenor, A.G. (deposition date: 2008-08-18, release date: 2008-09-09, Last modification date: 2023-08-30)
Primary citation	Shaw, D.,Wang, S.M.,Villasenor, A.G.,Tsing, S.,Walter, D.,Browner, M.F.,Barnett, J.,Kuglstatter, A. The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity. J.Mol.Biol., 383:885-893, 2008 Cited by PubMed: 18801372 DOI: 10.1016/j.jmb.2008.08.086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation