3E62

Fragment based discovery of JAK-2 inhibitors

Summary for 3E62

Entry DOI	10.2210/pdb3e62/pdb
Related	3E63 3E64
Descriptor	Tyrosine-protein kinase JAK2, 5-bromo-1H-indazol-3-amine (3 entities in total)
Functional Keywords	drug discovery, jak2, fragment based, atp-binding, disease mutation, kinase, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system; Peripheral membrane protein (By similarity): O60674
Total number of polymer chains	1
Total formula weight	34890.54
Authors	Antonysamy, S.,Fang, W.,Hirst, G.,Park, F.,Russell, M.,Smyth, L.,Sprengeler, P.,Stappenbeck, F.,Steensma, R.,Thompson, D.A.,Wilson, M.,Wong, M.,Zhang, A.,Zhang, F. (deposition date: 2008-08-14, release date: 2008-10-14, Last modification date: 2012-02-08)
Primary citation	Antonysamy, S.,Hirst, G.,Park, F.,Sprengeler, P.,Stappenbeck, F.,Steensma, R.,Wilson, M.,Wong, M. Fragment-based discovery of JAK-2 inhibitors. Bioorg.Med.Chem.Lett., 19:279-282, 2009 Cited by PubMed: 19019674 DOI: 10.1016/j.bmcl.2008.08.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.922 Å)

Structure validation