3DRC

INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS

Summary for 3DRC

Entry DOI	10.2210/pdb3drc/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ... (5 entities in total)
Functional Keywords	oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	37060.51
Authors	Oatley, S.J.,Kraut, J. (deposition date: 1992-09-22, release date: 1994-01-31, Last modification date: 2024-02-21)
Primary citation	Warren, M.S.,Brown, K.A.,Farnum, M.F.,Howell, E.E.,Kraut, J. Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis. Biochemistry, 30:11092-11103, 1991 Cited by PubMed: 1932031 DOI: 10.1021/bi00110a011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation