3DOG

Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1

Summary for 3DOG

• Entry DOI: 10.2210/pdb3dog/pdb
• Descriptor: Cell division protein kinase 2, Cyclin-A2, (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol, ... (5 entities in total)
• Functional Keywords: ser/thr protein kinase; transferase; phosphorylation; cell cycle, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, cyclin, cytoplasm, nucleus
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P30274
• Total number of polymer chains: 4
• Total formula weight: 129892.25

Authors

Echalier, A.,Endicott, J. (deposition date: 2008-07-04, release date: 2008-09-30, Last modification date: 2024-04-03)

• Primary citation: Bettayeb, K.,Sallam, H.,Ferandin, Y.,Popowycz, F.,Fournet, G.,Hassan, M.,Echalier, A.,Bernard, P.,Endicott, J.,Joseph, B.,Meijer, L.; N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.; Mol.Cancer Ther., 7:2713-2724, 2008; PubMed: 18790752; DOI: 10.1158/1535-7163.MCT-08-0080

Experimental method

X-RAY DIFFRACTION (2.7 Å)