3DDS

Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK261

Summary for 3DDS

Entry DOI	10.2210/pdb3dds/pdb
Related	3DD1 3DDW
Descriptor	Glycogen phosphorylase, liver form, N-acetyl-beta-D-glucopyranosylamine, PHOSPHATE ION, ... (9 entities in total)
Functional Keywords	gp, glycogen phosphorylase, diabetes, allosteric enzyme, carbohydrate metabolism, disease mutation, glycogen metabolism, glycogen storage disease, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase
Biological source	Homo sapiens
Total number of polymer chains	2
Total formula weight	197928.98
Authors	Nolte, R.T. (deposition date: 2008-06-06, release date: 2009-01-27, Last modification date: 2023-08-30)
Primary citation	Thomson, S.A.,Banker, P.,Bickett, D.M.,Boucheron, J.A.,Carter, H.L.,Clancy, D.C.,Cooper, J.P.,Dickerson, S.H.,Garrido, D.M.,Nolte, R.T.,Peat, A.J.,Sheckler, L.R.,Sparks, S.M.,Tavares, F.X.,Wang, L.,Wang, T.Y.,Weiel, J.E. Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy. Bioorg.Med.Chem.Lett., 19:1177-1182, 2009 Cited by PubMed: 19138846 DOI: 10.1016/j.bmcl.2008.12.085 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation