3DCV

Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one

Summary for 3DCV

Entry DOI	10.2210/pdb3dcv/pdb
Descriptor	Proto-oncogene serine/threonine-protein kinase Pim-1, 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (3 entities in total)
Functional Keywords	ser/thr protein kinase, nucleotide-binding, phsphorylation, atp-binding, cancer, oncogene, alternative initiation, cytoplasm, manganese, membrane, metal-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	37875.01
Authors	Bellamacina, C.R.,Shafer, C.M.,Lindvall, M.,Gesner, T.G.,Yabannavar, A.,Weiping, J.,Song, L.,Walter, A. (deposition date: 2008-06-04, release date: 2008-08-19, Last modification date: 2024-04-03)
Primary citation	Shafer, C.M.,Lindvall, M.,Bellamacina, C.,Gesner, T.G.,Yabannavar, A.,Jia, W.,Lin, S.,Walter, A. 4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors. Bioorg.Med.Chem.Lett., 18:4482-4485, 2008 Cited by PubMed: 18672368 DOI: 10.1016/j.bmcl.2008.07.061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation