Summary for 3D9V
| Entry DOI | 10.2210/pdb3d9v/pdb |
| Descriptor | Rho-associated protein kinase 1, (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE (2 entities in total) |
| Functional Keywords | dimer, dimerization, kinase, phosphorylation, fasudil, apoptosis, atp-binding, coiled coil, cytoplasm, golgi apparatus, membrane, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, zinc, zinc-finger |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm: Q13464 |
| Total number of polymer chains | 2 |
| Total formula weight | 96663.41 |
| Authors | Jacobs, M. (deposition date: 2008-05-27, release date: 2008-06-10, Last modification date: 2024-02-21) |
| Primary citation | Jacobs, M.,Hayakawa, K.,Swenson, L.,Bellon, S.,Fleming, M.,Taslimi, P.,Doran, J. The structure of dimeric ROCK I reveals the mechanism for ligand selectivity. J.Biol.Chem., 281:260-268, 2006 Cited by PubMed: 16249185DOI: 10.1074/jbc.M508847200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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