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3D8W

Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

Summary for 3D8W
Entry DOI10.2210/pdb3d8w/pdb
DescriptorCarbonic anhydrase II, ZINC ION, 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide, ... (4 entities in total)
Functional Keywordscarbonic anhydrase ii, anti-cancer, benzolamide, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight29674.84
Authors
Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (deposition date: 2008-05-26, release date: 2009-03-03, Last modification date: 2023-08-30)
Primary citationGenis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R.
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48:1322-1331, 2009
Cited by
PubMed: 19170619
DOI: 10.1021/bi802035f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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