3D7V

Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand

Summary for 3D7V

• Entry DOI: 10.2210/pdb3d7v/pdb
• Related: 1WSX 2NL9 2NLA
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION, ... (4 entities in total)
• Functional Keywords: helical bundle, amphipathic helix, alternative splicing, apoptosis, cytoplasm, developmental protein, differentiation, membrane, mitochondrion, nucleus, phosphoprotein, polymorphism, transmembrane, ubl conjugation
• Biological source: Mus musculus (mouse, human); More
• Cellular location: Membrane ; Single-pass membrane protein : Q07820; Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• Total number of polymer chains: 2
• Total formula weight: 21645.74

Authors

Lee, E.F.,Czabotar, P.E.,Colman, P.M.,Fairlie, W.D. (deposition date: 2008-05-22, release date: 2008-06-24, Last modification date: 2023-11-01)

• Primary citation: Lee, E.F.,Czabotar, P.E.,van Delft, M.F.,Michalak, E.M.,Boyle, M.J.,Willis, S.N.,Puthalakath, H.,Bouillet, P.,Colman, P.M.,Huang, D.C.S.,Fairlie, W.D.; A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.; J.Cell Biol., 180:341-355, 2008; PubMed: 18209102; DOI: 10.1083/jcb.200708096

Experimental method

X-RAY DIFFRACTION (2.03 Å)