3D7P

Crystal structure of human Transthyretin (TTR) at pH 4.0

Summary for 3D7P

Entry DOI	10.2210/pdb3d7p/pdb
Related	1BMZ 3CBR
Descriptor	Transthyretin (2 entities in total)
Functional Keywords	wt-ttr, amyloid, transthyretin, acidic ph, native ttr, and crystal structure, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	27554.72
Authors	Palaninathan, S.K.,Mohamedmohaideen, N.N.,Snee, W.C.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2008-05-21, release date: 2008-08-12, Last modification date: 2023-08-30)
Primary citation	Palaninathan, S.K.,Mohamedmohaideen, N.N.,Snee, W.C.,Kelly, J.W.,Sacchettini, J.C. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J.Mol.Biol., 382:1157-1167, 2008 Cited by PubMed: 18662699 DOI: 10.1016/j.jmb.2008.07.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation