3D57

TR Variant D355R

Summary for 3D57

Entry DOI	10.2210/pdb3d57/pdb
Descriptor	Thyroid hormone receptor beta, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywords	thyroid hormone receptor, ligand binding domain, d355r mutant, homodimer, alternative splicing, deafness, disease mutation, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, hormone, transcription receptor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10828
Total number of polymer chains	2
Total formula weight	61595.48
Authors	Jouravel, N. (deposition date: 2008-05-15, release date: 2008-10-14, Last modification date: 2023-08-30)
Primary citation	Jouravel, N.,Sablin, E.,Togashi, M.,Baxter, J.D.,Webb, P.,Fletterick, R.J. Molecular basis for dimer formation of TRbeta variant D355R. Proteins, 75:111-117, 2008 Cited by PubMed: 18798561 DOI: 10.1002/prot.22225 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation