3D4B

Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+

Summary for 3D4B

• Entry DOI: 10.2210/pdb3d4b/pdb
• Descriptor: NAD-dependent deacetylase, Acetyl P53 peptide, ZINC ION, ... (5 entities in total)
• Functional Keywords: rossmann fold, cytoplasm, hydrolase, metal-binding, nad, zinc
• Biological source: Thermotoga maritima
• Cellular location: Cytoplasm (Probable): Q9WYW0
• Total number of polymer chains: 2
• Total formula weight: 29409.07

Authors

Hawse, W.F.,Hoff, K.G.,Fatkins, D.,Daines, A.,Zubkova, O.V.,Schramm, V.L.,Zheng, W.,Wolberger, C. (deposition date: 2008-05-14, release date: 2008-09-30, Last modification date: 2011-07-13)

• Primary citation: Hawse, W.F.,Hoff, K.G.,Fatkins, D.G.,Daines, A.,Zubkova, O.V.,Schramm, V.L.,Zheng, W.,Wolberger, C.; Structural insights into intermediate steps in the Sir2 deacetylation reaction.; Structure, 16:1368-1377, 2008; PubMed: 18786399; DOI: 10.1016/j.str.2008.05.015

Experimental method

X-RAY DIFFRACTION (1.9 Å)