3D2I

Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-{5-[2-(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylamino)-ethyl]-thiazol-2-yl}-3-(3-trifluoromethyl-phenyl)-urea

Summary for 3D2I

• Entry DOI: 10.2210/pdb3d2i/pdb
• Related: 3D2K 3d14 3d15
• Descriptor: serine/threonine kinase 6, 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
• Functional Keywords: aurora a, small-molecule inhibitor, kinase, transferase
• Biological source: Mus musculus (mouse)
• Total number of polymer chains: 1
• Total formula weight: 32011.63

Authors

Oslob, J.D.,Yu, C.,Romanowski, M.J. (deposition date: 2008-05-08, release date: 2009-05-12, Last modification date: 2023-08-30)

• Primary citation: Oslob, J.D.,Yu, C.,Allen, D.A.,Baskaran, S.,Maung, J.,Michelotti, E.F.,Elling, R.A.,Romanowski, M.J.; Discovery of Aurora-A-selective inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.9 Å)