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3D25

Crystal structure of HA-1 minor histocompatibility antigen bound to human class I MHC HLA-A2

Summary for 3D25
Entry DOI10.2210/pdb3d25/pdb
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Nonameric peptide from HA-1, ... (4 entities in total)
Functional Keywordsmhc, hla-a2, secondary anchor residue, glycoprotein, immune system, minor histocompatibility antigen, stem cell transplantation, immune response
Biological sourceHomo sapiens (Human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted: P61769
Total number of polymer chains3
Total formula weight44385.22
Authors
Primary citationNicholls, S.,Piper, K.P.,Mohammed, F.,Dafforn, T.R.,Tenzer, S.,Salim, M.,Mahendra, P.,Craddock, C.,van Endert, P.,Schild, H.,Cobbold, M.,Engelhard, V.H.,Moss, P.A.,Willcox, B.E.
Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition
Proc.Natl.Acad.Sci.USA, 106:3889-3894, 2009
Cited by
PubMed: 19234124
DOI: 10.1073/pnas.0900411106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.3 Å)
Structure validation

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