3CYU

Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon

Summary for 3CYU

Entry DOI	10.2210/pdb3cyu/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, MoMo-2-[4-(2-(4-(methoxy)-1H-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1H-1,2,3-triazol-1-y l)propanoic acid]-cryptophane-A, ... (6 entities in total)
Functional Keywords	zinc metalloenzyme, sulfonamide, cryptophane, xenon, biosensor, disease mutation, lyase, metal-binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	32464.06
Authors	Aaron, J.A.,Jude, K.M.,Di Costanzo, L.,Christianson, D.W. (deposition date: 2008-04-26, release date: 2008-05-27, Last modification date: 2023-08-30)
Primary citation	Aaron, J.A.,Chambers, J.M.,Jude, K.M.,Di Costanzo, L.,Dmochowski, I.J.,Christianson, D.W. Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II. J.Am.Chem.Soc., 130:6942-6943, 2008 Cited by PubMed: 18461940 DOI: 10.1021/ja802214x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation