3CTQ

Structure of MAP kinase p38 in complex with a 1-o-tolyl-1,2,3-triazole-4-carboxamide

Summary for 3CTQ

Entry DOI	10.2210/pdb3ctq/pdb
Descriptor	Mitogen-activated protein kinase 14, N-benzyl-1-[5-({5-tert-butyl-2-methoxy-3-[(methylsulfonyl)amino]phenyl}carbamoyl)-2-methylphenyl]-1H-1,2,3-triazole-4-carboxamide (3 entities in total)
Functional Keywords	two lobe kinase fold, n-terminal beta-sheet, c-terminal alpha-helix, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (man)
Cellular location	Cytoplasm: Q16539
Total number of polymer chains	1
Total formula weight	40391.28
Authors	Qian, K. (deposition date: 2008-04-14, release date: 2008-05-27, Last modification date: 2024-02-21)
Primary citation	Cogan, D.A.,Aungst, R.,Breinlinger, E.C.,Fadra, T.,Goldberg, D.R.,Hao, M.H.,Kroe, R.,Moss, N.,Pargellis, C.,Qian, K.C.,Swinamer, A.D. Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 18:3251-3255, 2008 Cited by PubMed: 18462940 DOI: 10.1016/j.bmcl.2008.04.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation