3CSY

Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor

Summary for 3CSY

Entry DOI	10.2210/pdb3csy/pdb
Descriptor	Fab KZ52 heavy chain, Fab KZ52 light chain, Envelope glycoprotein GP1, ... (8 entities in total)
Functional Keywords	glycoprotein-antibody complex, immune system-viral protein complex, immune system/viral protein
Biological source	Homo sapiens (human) More
Cellular location	GP2: Virion membrane; Single-pass type I membrane protein. GP1: Virion membrane; Peripheral membrane protein. GP2-delta: Secreted: Q05320 GP2: Virion membrane; Single-pass type I membrane protein (By similarity). GP1: Virion membrane; Peripheral membrane protein (By similarity). GP2-delta: Secreted (By similarity): P87666
Total number of polymer chains	16
Total formula weight	406070.53
Authors	Lee, J.E.,Fusco, M.L.,Hessell, A.J.,Oswald, W.B.,Burton, D.R.,Saphire, E.O. (deposition date: 2008-04-10, release date: 2008-07-08, Last modification date: 2021-10-20)
Primary citation	Lee, J.E.,Fusco, M.L.,Hessell, A.J.,Oswald, W.B.,Burton, D.R.,Saphire, E.O. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature, 454:177-182, 2008 Cited by PubMed: 18615077 DOI: 10.1038/nature07082 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation