3CSI

Crystal Structure of the Glutathione Transferase Pi allelic variant*C, I104V/A113V, in complex with the Chlorambucil-Glutathione Conjugate

Summary for 3CSI

Entry DOI	10.2210/pdb3csi/pdb
Related	3CSH 3CSJ
Descriptor	Glutathione S-transferase P, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (9 entities in total)
Functional Keywords	transferase, glutathione, detoxification, chlorambucil, allelic variant
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	97575.81
Authors	Parker, L.J. (deposition date: 2008-04-09, release date: 2008-07-01, Last modification date: 2023-08-30)
Primary citation	Parker, L.J.,Ciccone, S.,Italiano, L.C.,Primavera, A.,Oakley, A.J.,Morton, C.J.,Hancock, N.C.,Bello, M.L.,Parker, M.W. The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants. J.Mol.Biol., 380:131-144, 2008 Cited by PubMed: 18511072 DOI: 10.1016/j.jmb.2008.04.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation