3CS4

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

Summary for 3CS4

Entry DOI	10.2210/pdb3cs4/pdb
Related	3CS6
Descriptor	Vitamin D3 receptor, (1S,3R,5Z,7E,14beta,17alpha)-17-[(2S,4S)-4-(2-hydroxy-2-methylpropyl)-2-methyltetrahydrofuran-2-yl]-9,10-secoandrosta-5,7,10-triene-1,3-diol (3 entities in total)
Functional Keywords	vdr, superagonist, disease mutation, dna-binding, metal-binding, nucleus, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, gene regulation
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P11473
Total number of polymer chains	1
Total formula weight	30249.99
Authors	Hourai, S.,Rodriguez, L.C.,Antony, P.,Reina-San-Martin, B.,Ciesielski, F.,Magnier, B.C.,Schoonjans, K.,Mourino, A.,Rochel, N.,Moras, D. (deposition date: 2008-04-09, release date: 2008-05-27, Last modification date: 2024-02-21)
Primary citation	Hourai, S.,Rodrigues, L.C.,Antony, P.,Reina-San-Martin, B.,Ciesielski, F.,Magnier, B.C.,Schoonjans, K.,Mourino, A.,Rochel, N.,Moras, D. Structure-based design of a superagonist ligand for the vitamin d nuclear receptor. Chem.Biol., 15:383-392, 2008 Cited by PubMed: 18420145 DOI: 10.1016/j.chembiol.2008.03.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation