3CQZ
Crystal structure of 10 subunit RNA polymerase II in complex with the inhibitor alpha-amanitin
Summary for 3CQZ
Entry DOI | 10.2210/pdb3cqz/pdb |
Related | 1K83 2VUM |
Related PRD ID | PRD_000201 |
Descriptor | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4, ALPHA-AMANITIN, ... (13 entities in total) |
Functional Keywords | transcription-toxin complex, alpha amanitin, toxin, inhibitor, polymerase, transferase, dna binding, zinc-finger, phosphoprotein, transcription, transcription/toxin |
Biological source | SACCHAROMYCES CEREVISIAE (BREWER'S YEAST, LAGER BEER YEAST, YEAST) More |
Cellular location | Nucleus: P04050 P08518 P16370 P20434 P20436 P27999 P38902 Nucleus, nucleolus: P40422 P22139 Cytoplasm: P20435 |
Total number of polymer chains | 11 |
Total formula weight | 471088.25 |
Authors | Kaplan, C.D.,Larsson, K.-M.,Kornberg, R.D. (deposition date: 2008-04-03, release date: 2008-07-22, Last modification date: 2023-08-30) |
Primary citation | Kaplan, C.D.,Larsson, K.M.,Kornberg, R.D. The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin. Mol.Cell, 30:547-, 2008 Cited by PubMed: 18538653DOI: 10.1016/J.MOLCEL.2008.04.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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