3CPU

SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT

Summary for 3CPU

Entry DOI	10.2210/pdb3cpu/pdb
Related PRD ID	PRD_900001
Descriptor	Pancreatic alpha-amylase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
Functional Keywords	amylase, acarbose, mutagenesis, diabetes, catalysis, pancreatic, enzyme, human, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	56348.15
Authors	Brayer, G.D.,Sidhu, G.,Maurus, R.,Rydberg, E.H.,Braun, C.,Wang, Y.,Nguyen, N.T.,Overall, C.M.,Withers, S.G. (deposition date: 1999-06-08, release date: 2001-06-30, Last modification date: 2023-12-27)
Primary citation	Brayer, G.D.,Sidhu, G.,Maurus, R.,Rydberg, E.H.,Braun, C.,Wang, Y.,Nguyen, N.T.,Overall, C.M.,Withers, S.G. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39:4778-4791, 2000 Cited by PubMed: 10769135 DOI: 10.1021/bi9921182 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation