3CLD

Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate

Summary for 3CLD

• Entry DOI: 10.2210/pdb3cld/pdb
• Related: 1m2z
• Descriptor: Glucocorticoid receptor, Tif2 coactivator motif, (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate, ... (4 entities in total)
• Functional Keywords: glucocorticoid receptor, gr, nuclear receptor, alternative initiation, chromatin regulator, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, pseudohermaphroditism, steroid-binding, transcription, transcription regulation, zinc-finger
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm. Isoform Beta: Nucleus: P04150
• Total number of polymer chains: 4
• Total formula weight: 64006.35

Authors

Shewchuk, L.M.,McLay, I.,Stewart, E.,Biggadike, K.B.,Hassell, A.M.,Bledsoe, R.K. (deposition date: 2008-03-18, release date: 2008-06-24, Last modification date: 2023-08-30)

• Primary citation: Biggadike, K.,Bledsoe, R.K.,Hassell, A.M.,Kirk, B.E.,McLay, I.M.,Shewchuk, L.M.,Stewart, E.L.; X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.; J.Med.Chem., 51:3349-3352, 2008; PubMed: 18522385; DOI: 10.1021/jm800279t

Experimental method

X-RAY DIFFRACTION (2.84 Å)