3CKI

Crystal structure of the TACE-N-TIMP-3 complex

Summary for 3CKI

Entry DOI	10.2210/pdb3cki/pdb
Descriptor	ADAM 17, Metalloproteinase inhibitor 3, ZINC ION, ... (5 entities in total)
Functional Keywords	extra-cellular matrix, catalytic zinc, sa-sb loop, alternative splicing, cleavage on pair of basic residues, glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen, disease mutation, extracellular matrix, metalloenzyme inhibitor, metalloprotease inhibitor, secreted, sensory transduction, vision, hydrolase, hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P78536 Secreted, extracellular space, extracellular matrix: P35625
Total number of polymer chains	2
Total formula weight	43016.13
Authors	Wisniewska, M.,Goettig, P.,Maskos, K.,Belouski, E.,Winters, D.,Hecht, R.,Black, R.,Bode, W. (deposition date: 2008-03-15, release date: 2008-08-05, Last modification date: 2023-08-30)
Primary citation	Wisniewska, M.,Goettig, P.,Maskos, K.,Belouski, E.,Winters, D.,Hecht, R.,Black, R.,Bode, W. Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex. J.Mol.Biol., 381:1307-1319, 2008 Cited by PubMed: 18638486 DOI: 10.1016/j.jmb.2008.06.088 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation