3CGF

IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding

Summary for 3CGF

Entry DOI	10.2210/pdb3cgf/pdb
Related	2P33
Descriptor	Mitogen-activated protein kinase 10, N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine (2 entities in total)
Functional Keywords	kinase two-lobed structure, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, epilepsy, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P53779
Total number of polymer chains	1
Total formula weight	42424.12
Authors	Ceska, T.A.,Platt, A.,Fortunato, M.,Dickson, K.M.,Buckley, G. (deposition date: 2008-03-05, release date: 2008-06-03, Last modification date: 2023-11-01)
Primary citation	Buckley, G.M.,Ceska, T.A.,Fraser, J.L.,Gowers, L.,Groom, C.R.,Higueruelo, A.P.,Jenkins, K.,Mack, S.R.,Morgan, T.,Parry, D.M.,Pitt, W.R.,Rausch, O.,Richard, M.D.,Sabin, V. IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding Bioorg.Med.Chem.Lett., 18:3291-3295, 2008 Cited by PubMed: 18482836 DOI: 10.1016/j.bmcl.2008.04.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation