3CF5

Thiopeptide antibiotic Thiostrepton bound to the large ribosomal subunit of Deinococcus radiodurans

Summary for 3CF5

Entry DOI	10.2210/pdb3cf5/pdb
Related	1D8T 1E9W 1OLN 2C77 2JQ7 2ZJP
Related PRD ID	PRD_000223
Descriptor	50S RIBOSOMAL PROTEIN L33, 50S RIBOSOMAL PROTEIN L6, 50S RIBOSOMAL PROTEIN L11, ... (32 entities in total)
Functional Keywords	ribosome-antibiotic complex, antibiotic, ribosome, thiostrepton, rna, l11, thiopeptide, thiazole, thiazoline, pyridine, translation inhibition, ribosome/antibiotic
Biological source	DEINOCOCCUS RADIODURANS More
Total number of polymer chains	31
Total formula weight	1367119.57
Authors	Harms, J.M.,Wilson, D.N.,Schluenzen, F.,Connell, S.R.,Stachelhaus, T.,Zaborowska, Z.,Spahn, C.M.T.,Fucini, P. (deposition date: 2008-03-02, release date: 2008-06-17, Last modification date: 2023-11-15)
Primary citation	Harms, J.M.,Wilson, D.N.,Schluenzen, F.,Connell, S.R.,Stachelhaus, T.,Zaborowska, Z.,Spahn, C.M.,Fucini, P. Translational Regulation Via L11: Molecular Switches on the Ribosome Turned on and Off by Thiostrepton and Micrococcin. Mol.Cell, 30:26-, 2008 Cited by PubMed: 18406324 DOI: 10.1016/J.MOLCEL.2008.01.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation