3CEJ

Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE2865

Summary for 3CEJ

Entry DOI	10.2210/pdb3cej/pdb
Related	3CEH 3CEM
Descriptor	Glycogen phosphorylase, liver form, N-acetyl-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
Functional Keywords	protein ligand complex, tense state, allosteric inhibitor, allosteric enzyme, carbohydrate metabolism, disease mutation, glycogen metabolism, glycogen storage disease, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	187975.50
Authors	Wendt, K.U.,Dreyer, M.K.,Anderka, O.,Klabunde, T.,Loenze, P.,Defossa, E.,Schmoll, D. (deposition date: 2008-02-29, release date: 2008-05-27, Last modification date: 2020-07-29)
Primary citation	Anderka, O.,Loenze, P.,Klabunde, T.,Dreyer, M.K.,Defossa, E.,Wendt, K.U.,Schmoll, D. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry, 47:4683-4691, 2008 Cited by PubMed: 18373353 DOI: 10.1021/bi702397d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation