3CDG

Human CD94/NKG2A in complex with HLA-E

Summary for 3CDG

• Entry DOI: 10.2210/pdb3cdg/pdb
• Descriptor: HLA class I histocompatibility antigen, alpha chain E, Beta-2-microglobulin, Natural killer cells antigen CD94, ... (5 entities in total)
• Functional Keywords: nk cell receptor, immunity, c-type lectin, mhc, glycoprotein, immune response, membrane, mhc i, polymorphism, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, alternative splicing, signal-anchor, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P13747 P17693; Secreted: P61769; Membrane; Single-pass type II membrane protein: Q13241 P26715
• Total number of polymer chains: 10
• Total formula weight: 145509.85

Authors

Petrie, E.J.,Clements, C.S.,Lin, J.,Sullivan, L.C.,Johnson, D.,Huyton, T.,Heroux, A.,Hoare, H.L.,Beddoe, T.,Reid, H.H.,Wilce, M.C.J.,Brooks, A.G.,Rossjohn, J. (deposition date: 2008-02-26, release date: 2008-04-22, Last modification date: 2023-11-01)

• Primary citation: Petrie, E.J.,Clements, C.S.,Lin, J.,Sullivan, L.C.,Johnson, D.,Huyton, T.,Heroux, A.,Hoare, H.L.,Beddoe, T.,Reid, H.H.,Wilce, M.C.J.,Brooks, A.G.,Rossjohn, J.; CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence; J.Exp.Med., 205:725-735, 2008; PubMed: 18332182; DOI: 10.1084/jem.20072525

Experimental method

X-RAY DIFFRACTION (3.4 Å)