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3CAJ

Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide

Summary for 3CAJ
Entry DOI10.2210/pdb3caj/pdb
Related1A42 1CA2 1CIL
DescriptorCarbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywordsprotein-inhibitor complex, disease mutation, lyase, metal-binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P00918
Total number of polymer chains1
Total formula weight30062.04
Authors
Di Fiore, A.,De Simone, G. (deposition date: 2008-02-20, release date: 2008-04-08, Last modification date: 2023-11-01)
Primary citationDi Fiore, A.,Pedone, C.,Antel, J.,Waldeck, H.,Witte, A.,Wurl, M.,Scozzafava, A.,Supuran, C.T.,De Simone, G.
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
Bioorg.Med.Chem.Lett., 18:2669-2674, 2008
Cited by
PubMed: 18359629
DOI: 10.1016/j.bmcl.2008.03.023
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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