3C9W

Crystal Structure of ERK-2 with hypothemycin covalently bound

Summary for 3C9W

Entry DOI	10.2210/pdb3c9w/pdb
Related	1ERK 2E14
Descriptor	Mitogen-activated protein kinase 1, (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione (3 entities in total)
Functional Keywords	erk, acetylation, atp-binding, cell cycle, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Rattus norvegicus (Rat)
Cellular location	Cytoplasm, cytoskeleton, spindle : P63086
Total number of polymer chains	2
Total formula weight	83155.46
Authors	Rosenfeld, R.J. (deposition date: 2008-02-18, release date: 2008-07-08, Last modification date: 2023-11-01)
Primary citation	Rastelli, G.,Rosenfeld, R.,Reid, R.,Santi, D.V. Molecular modeling and crystal structure of ERK2-hypothemycin complexes J.Struct.Biol., 164:18-23, 2008 Cited by PubMed: 18571434 DOI: 10.1016/j.jsb.2008.05.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation