3C7P
Crystal structure of human carbonic anhydrase II in complex with STX237
Summary for 3C7P
Entry DOI | 10.2210/pdb3c7p/pdb |
Related | 2gd8 3bet |
Descriptor | Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | protein-inhibitor complex, disease mutation, lyase, metal-binding |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30273.27 |
Authors | Di Fiore, A.,De Simone, G. (deposition date: 2008-02-08, release date: 2009-01-13, Last modification date: 2023-11-01) |
Primary citation | Woo, L.W.L.,Fischer, D.S.,Sharland, C.M.,Trusselle, M.,Foster, P.A.,Chander, S.K.,Di Fiore, A.,Supuran, C.T.,De Simone, G.,Purohit, A.,Reed, M.J.,Potter, B.V.L. Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography Mol.Cancer Ther., 7:2435-2444, 2008 Cited by PubMed: 18723489DOI: 10.1158/1535-7163.MCT-08-0195 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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