3C5U

P38 ALPHA map kinase complexed with a benzothiazole based inhibitor

Summary for 3C5U

Entry DOI	10.2210/pdb3c5u/pdb
Descriptor	Mitogen-activated protein kinase 14, 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, kinase, transferase, p38 map kinase, alternative splicing, atp-binding, cytoplasm, nucleotide-binding, nucleus, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	42811.83
Authors	Sack, J.S. (deposition date: 2008-02-01, release date: 2008-03-25, Last modification date: 2024-02-21)
Primary citation	Liu, C.,Lin, J.,Pitt, S.,Zhang, R.F.,Sack, J.S.,Kiefer, S.E.,Kish, K.,Doweyko, A.M.,Zhang, H.,Marathe, P.H.,Trzaskos, J.,Mckinnon, M.,Dodd, J.H.,Barrish, J.C.,Schieven, G.L.,Leftheris, K. Benzothiazole based inhibitors of p38alpha MAP kinase. Bioorg.Med.Chem.Lett., 18:1874-1879, 2008 Cited by PubMed: 18296051 DOI: 10.1016/j.bmcl.2008.02.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation