3C56

Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(3-Hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor

Summary for 3C56

• Entry DOI: 10.2210/pdb3c56/pdb
• Related: 3C4U 3C52
• Descriptor: Fructose-bisphosphate aldolase, ZINC ION, 3-{hydroxy[(phosphonooxy)acetyl]amino}propyl dihydrogen phosphate, ... (4 entities in total)
• Functional Keywords: class ii, fbp, aldolase, glycolysis, inhibitor, lyase, metal-binding, zinc
• Biological source: Helicobacter pylori
• Total number of polymer chains: 2
• Total formula weight: 68350.65

Authors

Coincon, M.,Sygusch, J.,Potvin-Dulude, P. (deposition date: 2008-01-30, release date: 2008-08-26, Last modification date: 2024-04-03)

• Primary citation: Fonvielle, M.,Coincon, M.,Daher, R.,Desbenoit, N.,Kosieradzka, K.,Barilone, N.,Gicquel, B.,Sygusch, J.,Jackson, M.,Therisod, M.; Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics.; Chemistry, 14:8521-8529, 2008; PubMed: 18688832; DOI: 10.1002/chem.200800857

Experimental method

X-RAY DIFFRACTION (2.3 Å)