3C4E

Pim-1 Kinase Domain in Complex with 3-aminophenyl-7-azaindole

Summary for 3C4E

• Entry DOI: 10.2210/pdb3c4e/pdb
• Related: 3C4C 3C4D 3C4F
• Descriptor: Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine, ... (4 entities in total)
• Functional Keywords: pim-1, proto-oncogene, serine/threonine kinase, alternative initiation, atp-binding, cytoplasm, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 4
• Total formula weight: 127184.51

Authors

Zhang, K.Y.J.,Wang, W. (deposition date: 2008-01-29, release date: 2008-02-26, Last modification date: 2024-02-21)

• Primary citation: Tsai, J.,Lee, J.T.,Wang, W.,Zhang, J.,Cho, H.,Mamo, S.,Bremer, R.,Gillette, S.,Kong, J.,Haass, N.K.,Sproesser, K.,Li, L.,Smalley, K.S.,Fong, D.,Zhu, Y.L.,Marimuthu, A.,Nguyen, H.,Lam, B.,Liu, J.,Cheung, I.,Rice, J.,Suzuki, Y.,Luu, C.,Settachatgul, C.,Shellooe, R.,Cantwell, J.,Kim, S.H.,Schlessinger, J.,Zhang, K.Y.,West, B.L.,Powell, B.,Habets, G.,Zhang, C.,Ibrahim, P.N.,Hirth, P.,Artis, D.R.,Herlyn, M.,Bollag, G.; Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity; Proc.Natl.Acad.Sci.Usa, 105:3041-3046, 2008; PubMed: 18287029; DOI: 10.1073/pnas.0711741105

Experimental method

X-RAY DIFFRACTION (1.98 Å)