3C2I
The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF
Summary for 3C2I
Entry DOI | 10.2210/pdb3c2i/pdb |
Descriptor | Methyl-CpG-binding protein 2, DNA (5'-D(*DTP*DCP*DTP*DGP*DGP*DAP*DAP*(5CM)P*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DTP*DTP*DCP*DTP*DA)-3'), DNA (5'-D(*DAP*DTP*DAP*DGP*DAP*DAP*DGP*DAP*DAP*DTP*DTP*DCP*(5CM)P*DGP*DTP*DTP*DCP*DCP*DAP*DG)-3'), ... (4 entities in total) |
Functional Keywords | water mediated recognition, protein-methylated dna complex, asx-st-motif, disease mutation, dna-binding, nucleus, phosphoprotein, repressor, transcription regulator |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P51608 |
Total number of polymer chains | 3 |
Total formula weight | 23575.42 |
Authors | Ho, K.L.,McNae, I.W.,Schmiedeberg, L.,Klose, R.J.,Bird, A.P.,Walkinshaw, M.D. (deposition date: 2008-01-25, release date: 2008-05-13, Last modification date: 2021-11-10) |
Primary citation | Ho, K.L.,McNae, I.W.,Schmiedeberg, L.,Klose, R.J.,Bird, A.P.,Walkinshaw, M.D. MeCP2 binding to DNA depends upon hydration at methyl-CpG Mol.Cell, 29:525-531, 2008 Cited by PubMed: 18313390DOI: 10.1016/j.molcel.2007.12.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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