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3C1X

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor

Summary for 3C1X
Entry DOI10.2210/pdb3c1x/pdb
DescriptorHepatocyte growth factor receptor, N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide (3 entities in total)
Functional Keywordsreceptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P08581
Total number of polymer chains1
Total formula weight42384.82
Authors
Sack, J. (deposition date: 2008-01-24, release date: 2008-03-18, Last modification date: 2024-02-21)
Primary citationSchroeder, G.M.,Chen, X.T.,Williams, D.K.,Nirschl, D.S.,Cai, Z.W.,Wei, D.,Tokarski, J.S.,An, Y.,Sack, J.,Chen, Z.,Huynh, T.,Vaccaro, W.,Poss, M.,Wautlet, B.,Gullo-Brown, J.,Kellar, K.,Manne, V.,Hunt, J.T.,Wong, T.W.,Lombardo, L.J.,Fargnoli, J.,Borzilleri, R.M.
Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.
Bioorg.Med.Chem.Lett., 18:1945-1951, 2008
Cited by
PubMed: 18289854
DOI: 10.1016/j.bmcl.2008.01.121
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.17 Å)
Structure validation

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