3BXQ

The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition

Summary for 3BXQ

Entry DOI	10.2210/pdb3bxq/pdb
Related	4INS
Descriptor	insulin A chain, insulin B chain, ZINC ION, ... (4 entities in total)
Functional Keywords	tr transition, electrostatic block, protein allostery, receptor binding, hormone
Cellular location	Secreted: P01308 P01308
Total number of polymer chains	4
Total formula weight	11804.21
Authors	Wan, Z.L.,Huang, K.,Hu, S.Q.,Whittaker, J.,Weiss, M.A. (deposition date: 2008-01-14, release date: 2008-05-20, Last modification date: 2023-08-30)
Primary citation	Wan, Z.L.,Huang, K.,Hu, S.Q.,Whittaker, J.,Weiss, M.A. The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J.Biol.Chem., 283:21198-21210, 2008 Cited by PubMed: 18492668 DOI: 10.1074/jbc.M800235200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation