3BWJ

Complex of PKA with the bisubstrate protein kinase inhibitor lead compound Arc-1034

Summary for 3BWJ

Entry DOI	10.2210/pdb3bwj/pdb
Related PRD ID	PRD_000645
Descriptor	cAMP-dependent protein kinase, alpha-catalytic subunit, (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-(6-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]amino}-6-oxohexyl)-3,4-dihydroxytetrahydrofuran-2-carboxamide (3 entities in total)
Functional Keywords	bisubstrate inhibitor, protein kinase, serine/threonine-protein kinase, atp-binding, camp, phosphoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Bos taurus (bovine)
Total number of polymer chains	1
Total formula weight	42197.93
Authors	Lavogina, D.,Koenig, N.,Uri, A.,Bossemeyer, D. (deposition date: 2008-01-09, release date: 2009-02-03, Last modification date: 2019-09-04)
Primary citation	Lavogina, D.,Lust, M.,Viil, I.,Konig, N.,Raidaru, G.,Rogozina, J.,Enkvist, E.,Uri, A.,Bossemeyer, D. Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases. J.Med.Chem., 52:308-321, 2009 Cited by PubMed: 19143565 DOI: 10.1021/jm800797n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation