3BPS

PCSK9:EGF-A complex

Summary for 3BPS

Entry DOI	10.2210/pdb3bps/pdb
Descriptor	Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION, ... (5 entities in total)
Functional Keywords	pcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, coated pit, egf-like domain, endocytosis, host-virus interaction, lipid transport, membrane, transmembrane, transport, hydrolase-lipid transport complex, hydrolase/lipid transport
Biological source	Homo sapiens (human) More
Cellular location	Secreted: Q8NBP7 Q8NBP7 Cell membrane; Single-pass type I membrane protein: P01130
Total number of polymer chains	3
Total formula weight	77857.85
Authors	Kwon, H.J. (deposition date: 2007-12-19, release date: 2008-02-12, Last modification date: 2023-08-30)
Primary citation	Kwon, H.J.,Lagace, T.A.,McNutt, M.C.,Horton, J.D.,Deisenhofer, J. Molecular basis for LDL receptor recognition by PCSK9. Proc.Natl.Acad.Sci.Usa, 105:1820-1825, 2008 Cited by PubMed: 18250299 DOI: 10.1073/pnas.0712064105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation