3BP7

The high resolution crystal structure of HLA-B*2709 in complex with a Cathepsin A signal sequence peptide, pCatA

Summary for 3BP7

• Entry DOI: 10.2210/pdb3bp7/pdb
• Related: 3BP4
• Descriptor: HLA class I histocompatibility antigen, B-27 alpha chain, Beta-2-microglobulin, nonameric peptide from Lysosomal protective protein, ... (5 entities in total)
• Functional Keywords: major histocompatibility complex, mhc, human leukocyte antigen, hla, hla-b*2709, hla-b2709, beta-2-microglobulin, b2m, cathepsin a signal sequence, pcata, ankylosing spondylitis, glycoprotein, host-virus interaction, immune response, membrane, mhc i, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, carboxypeptidase, hydrolase, lysosome, protease, zymogen, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P03989; Secreted . Note=(Microbial infection) In the presence of M: P61769; Lysosome: P10619
• Total number of polymer chains: 3
• Total formula weight: 44904.87

Authors

Kumar, P.,Vahedi-Faridi, A.,Saenger, W.,Uchanska-Ziegler, B.,Ziegler, A. (deposition date: 2007-12-18, release date: 2008-12-23, Last modification date: 2023-11-01)

• Primary citation: Kumar, P.,Vahedi-Faridi, A.,Saenger, W.,Merino, E.,Lopez de Castro, J.A.,Uchanska-Ziegler, B.,Ziegler, A.; Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens; J.Biol.Chem., 284:29784-29797, 2009; PubMed: 19617632; DOI: 10.1074/jbc.M109.038497

Experimental method

X-RAY DIFFRACTION (1.8 Å)