3BOW

Structure of M-calpain in complex with Calpastatin

Summary for 3BOW

• Entry DOI: 10.2210/pdb3bow/pdb
• Related: 1df0 1kfu 1kxr
• Descriptor: Calpain-2 catalytic subunit, Calpain small subunit 1, Calpastatin, ... (5 entities in total)
• Functional Keywords: cysteine protease, inhibitor, cell membrane, hydrolase, membrane, protease, thiol protease, phosphoprotein, protease inhibitor, thiol protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Cytoplasm (By similarity): Q07009; Cytoplasm: Q64537
• Total number of polymer chains: 3
• Total formula weight: 114049.26

Authors

Hanna, R.A.,Campbell, R.L.,Davies, P.L. (deposition date: 2007-12-17, release date: 2008-11-25, Last modification date: 2023-08-30)

• Primary citation: Hanna, R.A.,Campbell, R.L.,Davies, P.L.; Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin.; Nature, 456:409-412, 2008; PubMed: 19020623; DOI: 10.1038/nature07451

Experimental method

X-RAY DIFFRACTION (2.4 Å)