3BL0

Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies

Summary for 3BL0

Entry DOI	10.2210/pdb3bl0/pdb
Related	2EU2 2EU3 3BL1
Descriptor	Carbonic anhydrase 2, ZINC ION, 1-[5-(dimethylamino)-1,3,4-thiadiazol-2-yl]methanesulfonamide, ... (5 entities in total)
Functional Keywords	carbonic anhydrase, inhibitors, sulfonamide, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc, lyase(oxo-acid)
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29898.46
Authors	Temperini, C.,Supuran, C.T.,Blackburn, G.M. (deposition date: 2007-12-10, release date: 2008-01-22, Last modification date: 2024-02-21)
Primary citation	Temperini, C.,Cecchi, A.,Boyle, N.A.,Scozzafava, A.,Cabeza, J.E.,Wentworth, P.,Blackburn, G.M.,Supuran, C.T. Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies. Bioorg.Med.Chem.Lett., 18:999-1005, 2008 Cited by PubMed: 18162396 DOI: 10.1016/j.bmcl.2007.12.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation