3BJE

Crystal structure of Trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity

Summary for 3BJE

• Entry DOI: 10.2210/pdb3bje/pdb
• Descriptor: Nucleoside phosphorylase, putative, 1-O-phosphono-alpha-D-ribofuranose, URACIL, ... (5 entities in total)
• Functional Keywords: nucleoside phosphorylase, uridine phosphorylase, structural genomics, medical structural genomics of pathogenic protozoa consortium, msgpp, trypanosoma, brucei, sleeping sickness, glycosyltransferase, transferase, psi-2, protein structure initiative
• Biological source: Trypanosoma brucei
• Total number of polymer chains: 2
• Total formula weight: 76732.93

Authors

Larson, E.T.,Merritt, E.A.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (deposition date: 2007-12-03, release date: 2007-12-18, Last modification date: 2024-02-21)

• Primary citation: Larson, E.T.,Mudeppa, D.G.,Gillespie, J.R.,Mueller, N.,Napuli, A.J.,Arif, J.A.,Ross, J.,Arakaki, T.L.,Lauricella, A.,Detitta, G.,Luft, J.,Zucker, F.,Verlinde, C.L.,Fan, E.,Van Voorhis, W.C.,Buckner, F.S.,Rathod, P.K.,Hol, W.G.,Merritt, E.A.; The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase; J.Mol.Biol., 396:1244-1259, 2010; PubMed: 20070944; DOI: 10.1016/j.jmb.2010.01.013

Experimental method

X-RAY DIFFRACTION (1.44 Å)