3BJC

Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor

Summary for 3BJC

Entry DOI	10.2210/pdb3bjc/pdb
Descriptor	cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	pde5, erectile dysfunction, inhibitor design, allosteric enzyme, alternative splicing, cgmp, cgmp-binding, hydrolase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, polymorphism, zinc
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	100907.33
Authors	Chen, G.,Wang, H.,Howard, R.,Cai, J.,Wan, Y.,Ke, H. (deposition date: 2007-12-03, release date: 2008-04-29, Last modification date: 2024-04-03)
Primary citation	Chen, G.,Wang, H.,Robinson, H.,Cai, J.,Wan, Y.,Ke, H. An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies BIOCHEM.PHARM., 75:1717-1728, 2008 Cited by PubMed: 18346713 DOI: 10.1016/j.bcp.2008.01.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation