3BIZ

Wee1 kinase complex with inhibitor PD331618

Summary for 3BIZ

• Entry DOI: 10.2210/pdb3biz/pdb
• Related: 1X8B
• Descriptor: Wee1-like protein kinase, CHLORIDE ION, 4-(2-chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, ... (4 entities in total)
• Functional Keywords: kinase domain, inhibitor complex, atp-binding, cell cycle, cell division, magnesium, metal-binding, mitosis, nucleotide-binding, nucleus, phosphoprotein, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P30291
• Total number of polymer chains: 1
• Total formula weight: 32810.16

Authors

Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. (deposition date: 2007-12-02, release date: 2007-12-25, Last modification date: 2023-11-01)

• Primary citation: Smaill, J.B.,Lee, H.H.,Palmer, B.D.,Thompson, A.M.,Squire, C.J.,Baker, E.N.,Booth, R.J.,Kraker, A.,Hook, K.,Denny, W.A.; Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.; Bioorg.Med.Chem.Lett., 18:929-933, 2008; PubMed: 18191399; DOI: 10.1016/j.bmcl.2007.12.046

Experimental method

X-RAY DIFFRACTION (2.2 Å)